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Article

Mapping the Single-Cell Differentiation Landscape of Osteosarcoma

22 May 2024

Abstract excerpt

PURPOSE: The genetic intratumoral heterogeneity observed in human osteosarcomas poses challenges for drug development and the study of cell fate, plasticity, and differentiation, which are processes linked to tumor grade, cell metastasis, and survival. EXPERIMENTAL DESIGN: To pinpoint errors in osteosarcoma differentiation, we transcriptionally profiled 31,527 cells from a tissue-engineered model that directs...

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PMID: 38775859
DOI: 10.1158/1078-0432.ccr-24-0563

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