Article

HLA class II mediates type 1 diabetes risk by anti-insulin repertoire selection

2021-09-06

Abstract excerpt

Type 1 diabetes (T1D) is a common autoimmune disorder characterized by the destruction of insulin-secreting pancreatic β cells [1], in which polymorphism of the human leukocyte antigen (HLA) class II region is the major genetic risk factor [2, 3, 4]. However, how variation in class II molecules alters T1D risk remains a longstanding question. Here we show how T1D risk due to HLA class II haplotype combinations [5]...

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Literature Corpus work: 28fb8d2b-db6f-5b22-914a-08eda645cc28
DOI: 10.1101/2021.09.06.458974

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