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Article

The Chicken or the Egg Dilemma: Understanding the Interplay between the Immune System and the β Cell in Type 1 Diabetes.

Cold Spring Harbor perspectives in medicine - 1 Apr 2025

Hansen Maria Skjøtt, Pokharel Pravil, Piganelli Jon, Sussel Lori

Abstract excerpt

In this review, we explore the complex interplay between the immune system and pancreatic β cells in the context of type 1 diabetes (T1D). While T1D is predominantly considered a T-cell-mediated autoimmune disease, the inability of human leukocyte antigen (HLA)-risk alleles alone to explain disease development suggests a role for β cells in initiating and/or propagating disease. This review delves into the...

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Identifiers

PMID: 38951031
DOI: 10.1101/cshperspect.a041591
PMCID: PMC11960692

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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