Cracking the type 1 diabetes code: Genes, microbes, immunity, and the early life environment.

doi:10.1111/imr.13362

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Article

Cracking the type 1 diabetes code: Genes, microbes, immunity, and the early life environment.

Immunological reviews - 1 Aug 2024

Yau Christopher, Danska Jayne S

Abstract excerpt

Type 1 diabetes (T1D) results from a complex interplay of genetic predisposition, immunological dysregulation, and environmental triggers, that culminate in the destruction of insulin-secreting pancreatic β cells. This review provides a comprehensive examination of the multiple factors underpinning T1D pathogenesis, to elucidate key mechanisms and potential therapeutic targets. Beginning with an exploration of...

Topics

Diabetes Mellitus, Type 1
Humans
Animals
Genetic Predisposition to Disease
Gastrointestinal Microbiome
Autoimmunity
Insulin-Secreting Cells
Gene-Environment Interaction
Autoantibodies
HLA Antigens
Mice
Disease Models, Animal
Risk Factors

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Open in PubMed

Identifiers

PMID: 39166298
DOI: 10.1111/imr.13362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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