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The long and winding road to understanding and conquering type 1 diabetes.

Immunity - 23 Apr 2010

Santamaria Pere

Abstract excerpt

Autoimmune diseases with high population prevalence such as type 1 diabetes (T1D) develop as a result of ill-defined interactions between putative environmental triggers and a constellation of genetic elements scattered throughout the genome. In T1D, these interactions somehow trigger a loss of tolerance to pancreatic beta cells, manifested in the form of a chronic autoimmune response that mobilizes virtually...

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PMID: 20412754
DOI: 10.1016/j.immuni.2010.04.003

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