Article

A diagnostic plasma omics-biomarker for Alzheimer’s disease informed by microglial single-cell transcriptomics: A pilot study

2026-05-05

Abstract excerpt

<h4>Background</h4> The current biomarker framework for the diagnosis and staging of Alzheimer’s disease (AD) relies mainly on neuropathological features; thus, its performance for diagnosis is limited prior to the initiation of neurodegeneration. Here, we leveraged transcriptomic data to develop a new framework for omic-informed blood-based diagnostic biomarkers for AD from early-stage. <h4>Methods</h4> Microgl...

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Literature Corpus work: 5d80337c-c590-54a2-93b6-2b4db6e3ba0b
DOI: 10.64898/2026.04.30.721959

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