Article

Comprehensive adjudication identifies 111 high-confidence loci for Alzheimer's disease and related dementias

2026-05-19

Abstract excerpt

<h4>Background: </h4> The Alzheimer's Disease Sequencing Project Gene Verification Committee developed a systematic framework to adjudicate genetic evidence for AD and related dementias, addressing wide variation in association quality. <h4>Methods:</h4> Phase 1 established tiered criteria by evaluating 23 nominated loci across study designs. Phase 2 applied this framework to 29 large-scale genome-wide studies pub...

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Literature Corpus work: 7c4ea021-6133-573e-bdbb-ec0325fc57e6
DOI: 10.64898/2026.05.14.26353247

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