Article

Leveraging single cell RNA sequencing experiments to model intra-tumor heterogeneity

2018-09-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>PURPOSE</h4> Many cancers can be treated with targeted therapy. Almost inevitably, tumors develop resistance to targeted therapy, either from preexistence or by evolving new genotypes and traits. Intra-tumor heterogeneity serves as a reservoir for resistance, which often occurs due to selection of minor cellular sub-clones. On the level of gene expression, the ‘clonal’ heterogeneity can onl...

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Literature Corpus work: 02728528-7958-5222-ba02-44fdedb9fe29
DOI: 10.1101/427047

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