Article

A unifying framework disentangles genetic, epigenetic, and stochastic sources of drug-response variability in an <i>in vitro</i> model of tumor heterogeneity

2020-06-05

Abstract excerpt

<h4>ABSTRACT</h4> Tumor heterogeneity is a primary cause of treatment failure and acquired resistance in cancer patients. Even in cancers driven by a single mutated oncogene, variability of targeted therapy response is observed. Additional genetic mutations can only partially explain this variability, leading to consideration of non-genetic factors, such as “stem-like” and “mesenchymal” phenotypic states, as crit...

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Literature Corpus work: 5b57e993-afd0-5361-8c24-099504275392
DOI: 10.1101/2020.06.05.136119

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