Article

Genetic Heterogeneity Profiling by Single Cell RNA Sequencing

2018-10-30

Abstract excerpt

Detection of genetically distinct subclones and profiling the transcriptomic differences between them is important for studying the evolutionary dynamics of tumors, as well as for accurate prognosis and effective treatment of cancer in the clinic. For the profiling of intra-tumor transcriptional heterogeneity, single cell RNA-sequencing (scRNA-seq) is now ubiquitously adopted in ongoing and planned cancer studies....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a8ab3a74-0b9a-5537-b06a-144e493ba7c3
DOI: 10.1101/457622

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic Heterogeneity Profiling by Single Cell RNA SequencingDOI 10.1101/457622Read

Profiles of expressed mutations in single cells reveal subclonal expansion patterns and therapeutic impact of intratumor heterogeneitySemantic proximity Read

Single-cell RNA-seq variant analysis for exploration of genetic heterogeneity in cancerSemantic proximity Read

Single‐cell RNA sequencing in cancer researchSemantic proximity Read

Expression variation analysis for tumor heterogeneity in single-cell RNA-sequencing dataSemantic proximity Read

Tumor genetic analysis from single-cell RNA-seq data.Semantic proximity Read

Testing for phylogenetic signal in single-cell RNA-seq dataSemantic proximity Read

Single-cell RNA sequencing in melanoma: what have we learned so far?Semantic proximity Read

Single‐cell sequencing and tumorigenesis: improved understanding of tumor evolution and metastasisSemantic proximity Read

Leveraging Single-Cell RNA Sequencing Experiments to Model Intratumor HeterogeneitySemantic proximity Read

Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seqSemantic proximity Read

CHARTS: A web application for characterizing and comparing tumor subpopulations in publicly available single-cell RNA-seq datasetsSemantic proximity Read

Phylogenetic inference reveals clonal heterogeneity in circulating tumor cell clustersSemantic proximity Read