Article

Predicting heterogeneity in clone-specific therapeutic vulnerabilities using single-cell transcriptomic signatures

2020-11-24

Abstract excerpt

<h4>Summary</h4> While understanding heterogeneity in molecular signatures across patients underpins precision oncology, there is increasing appreciation for taking intra-tumor heterogeneity into account. Single-cell RNA-seq (scRNA-seq) technologies have facilitated investigations into the role of intra-tumor transcriptomic heterogeneity (ITTH) in tumor biology and evolution, but their application to in silico m...

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Literature Corpus work: 0bcfd2d6-f727-505f-8b13-ba3d088849b6
DOI: 10.1101/2020.11.23.389676

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