Article

The intra-tumour heterogeneity landscape of human cancers

2020-01-01

Abstract excerpt

Tumours accumulate many somatic mutations in their lifetime. Some of these mutations, drivers, convey a selective advantage and can induce clonal expansions. Incomplete clonal expansions give rise to intra-tumour heterogeneity. Somatic mutations can be measured through massively parallel sequencing, where mutations that are supporting incomplete expansions will appear as subclonal. These mutations can be used as a...

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Literature Corpus work: 0b14d733-633c-5dfb-977e-295fe506f380
DOI: 10.17863/cam.48225

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