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Unravelling glioblastoma heterogeneity by means of single-cell RNA sequencing

10 Dec 2021

Abstract excerpt

Glioblastoma (GBM) is the most invasive and deadliest brain cancer in adults. Its inherent heterogeneity has been designated as the main cause of treatment failure. Thus, a deeper understanding of the diversity that shapes GBM pathobiology is of utmost importance. Single-cell RNA sequencing (scRNA-seq) technologies have begun to uncover the hidden composition of complex tumor ecosystems. Herein, a semi-systematic...

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PMID: 34902524
DOI: 10.1016/j.canlet.2021.12.008

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