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Article

Leveraging Single-Cell RNA Sequencing Experiments to Model Intratumor Heterogeneity

17 Apr 2019

Abstract excerpt

PURPOSE: Many cancers can be treated with targeted therapy. Almost inevitably, tumors develop resistance to targeted therapy, either from pre-existence or by evolving new genotypes and traits. Intratumor heterogeneity serves as a reservoir for resistance, which often occurs as a result of the selection of minor cellular subclones. On the level of gene expression, clonal heterogeneity can only be revealed using...

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PMID: 30995123
DOI: 10.1200/cci.18.00074

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