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Computational Methods for Characterizing Cancer Mutational Heterogeneity

14 Jun 2017

Abstract excerpt

Advances in DNA sequencing technologies have allowed the characterization of somatic mutations in a large number of cancer genomes at an unprecedented level of detail, revealing the extreme genetic heterogeneity of cancer at two different levels: inter-tumor, with different patients of the same cancer type presenting different collections of somatic mutations, and intra-tumor, with different clones coexisting...

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PMID: 28659971
DOI: 10.3389/fgene.2017.00083

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