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Mitochondrial Gene Networks in Opioid Use Disorder: Multi-omic Evidence for Pathway-Specific Risk and Resilience

2026-02-16

Abstract excerpt

<title>Abstract</title> <p>Opioid use disorder (OUD) is a heritable, chronic relapsing condition, but the molecular pathways linking genetic risk to disease remain unclear. Using FinnGen GWAS data for opioid-related disorder (F11) as a genetic proxy, we integrated multi-omic quantitative trait loci for 1,136 mitochondrial genes, including methylation, expression, and protein QTLs. Using summary-data-based Mendeli...

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Literature Corpus work
02302dc6-764e-56b8-8cf5-0c2bdeabce54
DOI
10.21203/rs.3.rs-8434134/v1
Open publication

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Mitochondrial Gene Networks in Opioid Use Disorder: Multi-omic Evidence for Pathway-Specific Risk and ResilienceDOI 10.21203/rs.3.rs-8434134/v1
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