Article

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects on brain

2021-12-15

Abstract excerpt

Despite an estimated twin heritability of ∼50%, genome-wide association studies (GWAS) of opioid use disorder (OUD) have revealed few genome-wide significant (GWS) loci, with replicated findings only in European-ancestry individuals. To identify novel loci, including those in non-European ancestries, and improve our understanding of the biology of OUD, we conducted a cross-ancestry meta-analysis using the Million...

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Literature Corpus work: 5f40beca-0bed-5a73-bda3-b7ebff929c47
DOI: 10.1101/2021.12.13.21267480

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