Article
Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium.
Molecular psychiatry - 1 Aug 2020
Polimanti Renato, Walters Raymond K, Johnson Emma C, McClintick Jeanette N, Adkins Amy E, Adkins Daniel E, Bacanu Silviu-Alin, Bierut Laura J, Bigdeli Tim B, Brown Sandra, Bucholz Kathleen K, Copeland William E, Costello E Jane, Degenhardt Louisa, Farrer Lindsay A, Foroud Tatiana M, Fox Louis, Goate Alison M, Grucza Richard, Hack Laura M, Hancock Dana B, Hartz Sarah M, Heath Andrew C, Hewitt John K, Hopfer Christian J, Johnson Eric O, Kendler Kenneth S, Kranzler Henry R, Krauter Kenneth, Lai Dongbing, Madden Pamela A F, Martin Nicholas G, Maes Hermine H, Nelson Elliot C, Peterson Roseann E, Porjesz Bernice, Riley Brien P, Saccone Nancy, Stallings Michael, Wall Tamara L, Webb Bradley T, Wetherill Leah, Edenberg Howard J, Agrawal Arpana, Gelernter Joel
Abstract excerpt
To provide insights into the biology of opioid dependence (OD) and opioid use (i.e., exposure, OE), we completed a genome-wide analysis comparing 4503 OD cases, 4173 opioid-exposed controls, and 32,500 opioid-unexposed controls, including participants of European and African descent (EUR and AFR, respectively). Among the variants identified, rs9291211 was associated with OE (exposed vs. unexposed controls; EUR...
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