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Article

Mitochondria-Related Genome-Wide Mendelian Randomization Identifies Putatively Genes for Chronic Fatigue.

Molecular neurobiology - 29 Apr 2026

Zhang Zehan, Xiao Zhuoyang, Mei Heting, Qi Jun, Gao Yunan, Zhang Yifei, Li Feng

Abstract excerpt

Chronic fatigue is a debilitating symptom linked to mitochondrial dysfunction which lacks comprehensive genetic insights. This study aims to investigate mitochondrial-related genes associated with chronic fatigue and explores therapeutic targets. We conducted summary-data-based Mendelian randomization (SMR) and Bayesian colocalization analyses using blood eQTL data (n = 31,684) and fatigue GWAS data...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42053855
DOI: 10.1007/s12035-026-05896-8

Genes

AKAP10
MTHFD1L

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