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KIR Receptors as Key Regulators of NK Cells Activity in Health and Disease

14 Jul 2021

Abstract excerpt

Natural killer (NK) cells are part of the cellular immune response. They target mainly cancer and virally infected cells. To a high extent cytotoxic activity of NK cells is regulated inter alia by signals from killer immunoglobulin-like receptors (KIR). The major histocompatibility complex (MHC) class I molecules are important ligands for KIR receptors. Binding of ligands (such as MHC I) to the KIR receptors has...

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PMID: 34359951
DOI: 10.3390/cells10071777

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