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KIR2DL4 (CD158d): An activation receptor for HLA-G

1 Jan 2012

Abstract excerpt

KIR2DL4 is an unusual killer cell immunoglobulin-like receptor (KIR) family member in terms of its structure, expression, cellular localization, and signaling properties. The most conserved KIR in evolution, it is referred to as a framework KIR gene and is expressed by all natural killer (NK) cells and a subset of T cells. Although it has a long cytoplasmic tail that is typical of inhibitory KIR, engagement of...

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PMID: 22934097
DOI: 10.3389/fimmu.2012.00258

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