Article
KIR2DS5 allotypes that recognize the C2 epitope of HLA-C are common among Africans and absent from Europeans.
Immunity, inflammation and disease - 1 Dec 2017
Blokhuis Jeroen H, Hilton Hugo G, Guethlein Lisbeth A, Norman Paul J, Nemat-Gorgani Neda, Nakimuli Annettee, Chazara Olympe, Moffett Ashley, Parham Peter
Abstract excerpt
INTRODUCTION: KIR2DS5 is an activating human NK cell receptor of lineage III KIR. These include both inhibitory KIR2DL1, 2 and 3 and activating KIR2DS1 that recognize either the C1 or C2 epitope of HLA-C. In Europeans KIR2DS5 is essentially monomorphic, with KIR2DS5*002 being predominant. Pioneering investigations showed that KIR2DS5*002 has activating potential, but cannot recognize HLA-A, -B, or -C. Subsequent...
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