Article
Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis.
Cell reports - 3 Mar 2015
McKerrell Thomas, Park Naomi, Moreno Thaidy, Grove Carolyn S, Ponstingl Hannes, Stephens Jonathan, Crawley Charles, Craig Jenny, Scott Mike A, Hodkinson Clare, Baxter Joanna, Rad Roland, Forsyth Duncan R, Quail Michael A, Zeggini Eleftheria, Ouwehand Willem, Varela Ignacio, Vassiliou George S
Abstract excerpt
Clonal hemopoiesis driven by leukemia-associated gene mutations can occur without evidence of a blood disorder. To investigate this phenomenon, we interrogated 15 mutation hot spots in blood DNA from 4,219 individuals using ultra-deep sequencing. Using only the hot spots studied, we identified clonal hemopoiesis in 0.8% of individuals under 60, rising to 19.5% of those ≥90 years, thus predicting that clonal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.