Article
Genomic instability--an evolving hallmark of cancer.
Nature reviews. Molecular cell biology - 1 Mar 2010
Negrini Simona, Gorgoulis Vassilis G, Halazonetis Thanos D
Abstract excerpt
Genomic instability is a characteristic of most cancers. In hereditary cancers, genomic instability results from mutations in DNA repair genes and drives cancer development, as predicted by the mutator hypothesis. In sporadic (non-hereditary) cancers the molecular basis of genomic instability remains unclear, but recent high-throughput sequencing studies suggest that mutations in DNA repair genes are infrequent...
Topics
- Animals
- Ataxia Telangiectasia Mutated Proteins
- Cell Cycle Proteins
- Cyclin-Dependent Kinase Inhibitor p16
- DNA Damage
- DNA-Binding Proteins
- Genomic Instability
- Humans
- Models, Biological
- Mutation
- Neoplasms