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Article

DNA replication fidelity and cancer.

Seminars in cancer biology - 1 Oct 2010

Preston Bradley D, Albertson Tina M, Herr Alan J

Abstract excerpt

Cancer is fueled by mutations and driven by adaptive selection. Normal cells avoid deleterious mutations by replicating their genomes with extraordinary accuracy. Here we review the pathways governing DNA replication fidelity and discuss evidence implicating replication errors (point mutation instability or PIN) in carcinogenesis.

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Source

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Identifiers

PMID: 20951805
DOI: 10.1016/j.semcancer.2010.10.009
PMCID: PMC2993855

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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