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Article

Mutational signatures reveal ternary relationships between homologous recombination repair, APOBEC, and mismatch repair in gynecological cancers.

Journal of translational medicine - 2 Feb 2022

Farmanbar Amir, Firouzi Sanaz, Kneller Robert, Khiabanian Hossein

Abstract excerpt

BACKGROUND: Revealing the impacts of endogenous and exogenous mutagenesis processes is essential for understanding the etiology of somatic genomic alterations and designing precise prognostication and treatment strategies for cancer. DNA repair deficiency is one of the main sources of endogenous mutagenesis and is increasingly recognized as a target for cancer therapeutics. The role and prevalence of mechanisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35109853
DOI: 10.1186/s12967-022-03259-0
PMCID: PMC8812249

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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