Article

MASH: Mediation Analysis of Survival Outcome and High-dimensional Omics Mediators with Application to Complex Diseases

2023-08-23

Abstract excerpt

Environmental exposures such as cigarette smoking influence health out-comes through intermediate molecular phenotypes, such as the methylome, transcriptome, and metabolome. Mediation analysis is a useful tool for in-vestigating the role of potentially high-dimensional intermediate phenotypes in the relationship between environmental exposures and health outcomes. However, little work has been done on mediation an...

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Literature Corpus work: 0165dbbd-de79-5ab7-b92c-991cd073b87c
DOI: 10.1101/2023.08.22.554286

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