Article

MELODY: Mediation Analysis in Logistic Regression for High-Dimensional Mediators and a Binary Outcome

2025-11-13

Abstract excerpt

Mediation analysis is a pivotal tool for elucidating the indirect effect of an environmental factor or treatment on disease through potentially high-dimensional omics data, such as gene expression profiles. However, traditional mediation analysis methods tailored for binary outcomes often rely on the rare disease assumption in logistic regression and provide inadequate measures of total mediation effect when multi...

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Literature Corpus work: e8fd4523-291b-5468-89e7-bae75befad0b
DOI: 10.1101/2025.11.12.688038

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