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Article

Testing Mediation Effects in High-Dimensional Epigenetic Studies

22 Nov 2019

Abstract excerpt

Mediation analysis has been a powerful tool to identify factors mediating the association between exposure variables and outcomes. It has been applied to various genomic applications with the hope to gain novel insights into the underlying mechanism of various diseases. Given the high-dimensional nature of epigenetic data, recent effort on epigenetic mediation analysis is to first reduce the data dimension by...

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PMID: 31824577
DOI: 10.3389/fgene.2019.01195

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