Article

HDMAX2-surv: high-dimensional mediation analysis of survival data with application to pancreatic cancer

2025-09-15

Abstract excerpt

<h4>Motivation</h4> High-dimensional mediation analysis is critical for dissecting causal pathways in complex diseases. However, existing methods struggle to handle censored survival outcomes and unobserved confounders in epigenetic data. There is a pressing need for scalable, statistically robust frameworks to identify epigenetic mediators of exposure–outcome relationships, especially in cancer research where su...

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Literature Corpus work: c37d0e03-b158-5bb6-b7a7-575d2ca67145
DOI: 10.1101/2025.09.09.675033

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