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Article

Metabolites mediate genetic effects on disease in the Canadian Longitudinal Study on Aging

2025-11-14

Abstract excerpt

Understanding the biological mechanisms linking genetic variants to disease risk is essential for advancing precision health. We have developed a causal mediation analysis framework, the C-MAPLE (Causal Mediation Analysis of Pathways Linking Exposures) method, to identify disease-causing pathways for which the effect of genetic variants is mediated through metabolites to impact age-related diseases. Unlike Mendeli...

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Literature Corpus work
9a555539-fb4c-5012-97b9-adfbdd64876d
DOI
10.1101/2025.11.12.25339921
Open publication

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Metabolites mediate genetic effects on disease in the Canadian Longitudinal Study on AgingDOI 10.1101/2025.11.12.25339921
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