ESPLSM: An Efficient and Interpretable Mediation Analysis Framework Using Sparse Envelopes.

Abstract excerpt

Mediation analysis is a fundamental tool for understanding biological mechanisms through which an exposure exerts its effect on an outcome via intermediate variables, or mediators. However, modern biomedical studies often involve multiple exposures and mediators with complex correlation structures, and may also involve multiple outcomes, as in multi-omics or imaging studies, where existing mediation analyses can...

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