Article

A novel statistical framework for meta-analysis of total mediation effect with high dimensional omics mediators in large-scale genomic consortia

2024-04-30

Abstract excerpt

Meta-analysis is used to aggregate the effects of interest across multiple studies, while its methodology is largely underexplored in mediation analysis, particularly in estimating the total mediation effect of high-dimensional omics mediators. Large-scale genomic consortia, such as the Trans-Omics for Precision Medicine (TOPMed) program, comprise multiple cohorts with diverse technologies to elucidate the genetic...

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Literature Corpus work: eb9c6aad-96fc-503b-853e-378f047fe89b
DOI: 10.1101/2024.04.29.591700

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