Article

An M-learner approach for heterogeneous mediation analysis with high-dimensional omics mediators

2026-08-28

Abstract excerpt

Causal mediation analysis is widely used to identify biological pathways linking exposures to outcomes, but most methods assume homogeneous mediation effects across individuals. In high-dimensional omics settings, this assumption can mask important heterogeneity driven by demographic, genetic, or environmental factors. We propose the M-high-learner , a flexible framework for detecting heterogeneous mediation effe...

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Literature Corpus work: 16685d08-e04b-5d63-b048-d6011504ba17
DOI: 10.64898/2026.08.25.747106

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