Article

Single-cell and single-variant resolution analysis of clonal evolution in human liver cancer

2021-01-02

Abstract excerpt

Genetic heterogeneity of tumor is closely related to clonal evolution, phenotypic diversity and treatment resistance. Such heterogeneity has been characterized in liver cancer at single-cell sub-chromosomal scale, and a more precise single-variant resolution analysis is lacking. Here we employed a strategy to analyze both the single-cell genomic mutations and transcriptomic changes in 5 patients with liver cancer....

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Literature Corpus work: da436999-d1b2-5776-a342-31fb57f3265b
DOI: 10.1101/2020.12.30.424907

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