Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Variation in Enhancers Modifies Cardiomyopathy Gene Expression and Progression.

Circulation - 30 Mar 2021

Gacita Anthony M, Fullenkamp Dominic E, Ohiri Joyce, Pottinger Tess, Puckelwartz Megan J, Nobrega Marcelo A, McNally Elizabeth M

Abstract excerpt

BACKGROUND: Inherited cardiomyopathy associates with a range of phenotypes, mediated by genetic and nongenetic factors. Noninherited cardiomyopathy also displays varying progression and outcomes. Expression of cardiomyopathy genes is under the regulatory control of promoters and enhancers, and human genetic variation in promoters and enhancers may contribute to this variability. METHODS: We superimposed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac Myosins
Share to Cardiomyopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Congenital heart defects research

Share to Disease Progression

Share to Gene Expression

Share to Genetic Variation

Share to Myosin Heavy Chains

Share to Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 33478249
DOI: 10.1161/CIRCULATIONAHA.120.050432
PMCID: PMC8009836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Variation in Enhancers Modifies Cardiomyopathy Gene Expression and Progression.PMID 33478249Read ↗

A gene regulatory element modulates myosin expression and controls cardiomyocyte response to stressSemantic proximity Read ↗

Mammalian epigenomic conservation of promoters and enhancers in the heart associates with trait-associated variation and impacts cardiomyocyte phenotypesSemantic proximity Read ↗

Engineered Heart Tissues Facilitate Noncoding Variant Studies in Cardiomyopathy.Semantic proximity Read ↗

Cardiac Cell Type-Specific Gene Regulatory Programs and Disease Risk AssociationSemantic proximity Read ↗

Engineered heart tissues facilitate functional characterization of noncoding variants implicated in Hypertrophic and Dilated CardiomyopathySemantic proximity Read ↗

Genome-Wide Fetalization of Enhancer Architecture in Heart DiseaseSemantic proximity Read ↗

Genome-wide compendium and functional assessment of in vivo heart enhancers.Semantic proximity Read ↗

CHD-associated enhancers shape human cardiomyocyte lineage commitmentSemantic proximity Read ↗

Integrative Functional Annotation of 52 Genetic Loci Influencing Myocardial Mass Identifies Candidate Regulatory Variants and Target GenesSemantic proximity Read ↗

The Emerging Role of Epigenetics in Therapeutic Targeting of Cardiomyopathies.Semantic proximity Read ↗

Epigenetics, Modifiers, and Molecular Noise: Rethinking Pathophysiology in Dilated and Hypertrophic Cardiomyopathies.Semantic proximity Read ↗

Genome-wide enhancer-associated tandem repeats are expanded in cardiomyopathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.