Article
Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility.
Nucleic acids research - 7 Sept 2021
Charlesworth Amanda G, Seroussi Uri, Lehrbach Nicolas J, Renaud Mathias S, Sundby Adam E, Molnar Ruxandra I, Lao Robert X, Willis Alexandra R, Woock Jenna R, Aber Matthew J, Diao Annette J, Reinke Aaron W, Ruvkun Gary, Claycomb Julie M
Abstract excerpt
The Caenorhabditis elegans genome encodes nineteen functional Argonaute proteins that use 22G-RNAs, 26G-RNAs, miRNAs or piRNAs to regulate target transcripts. Only one Argonaute is essential under normal laboratory conditions: CSR-1. While CSR-1 has been studied widely, nearly all studies have overlooked the fact that the csr-1 locus encodes two isoforms. These isoforms differ by an additional 163 amino acids...
Topics
- Alleles
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Female
- Fertility
- Gene Expression
- Male
- Mutation
- Oocytes