Article

A role for the <i>C. elegans</i> Argonaute protein CSR-1b isoform in small nuclear RNA 3’ processing

2023-10-17

Abstract excerpt

<h4>ABSTRACT</h4> The Integrator is a multi-subunit protein complex that catalyzes the maturation of snRNA transcripts via 3’ cleavage, a step required for snRNA incorporation with snRNP for spliceosome biogenesis. Here we developed a GFP based in vivo snRNA misprocessing reporter as a readout of Integrator function and performed a genome-wide RNAi screen for Integrator regulators. We found that loss of the Argo...

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Literature Corpus work: 5f16c44a-5865-5373-94cc-09de7614aee1
DOI: 10.1101/2023.10.12.562094

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