Article

TIRTL-seq: Deep, quantitative, and affordable paired TCR repertoire sequencing

2024-09-21

Abstract excerpt

ɑ/β T cells are key players in adaptive immunity. The specificity of T cells is determined by the sequences of the hypervariable T cell receptor (TCR) ɑ and β chains. Although bulk TCR sequencing offers a cost-effective approach for in-depth TCR repertoire profiling, it does not provide chain pairings, which are essential for determining T cell specificity. In contrast, single-cell TCR sequencing technologies prod...

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Literature Corpus work: d1158c8b-2961-5f0d-a6c2-9da695dc7274
DOI: 10.1101/2024.09.16.613345

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