Article

Targeted reconstruction of T cell receptor sequence from single cell RNA-sequencing links CDR3 length to T cell differentiation state

2016-08-31

Abstract excerpt

<h4>ABSTRACT</h4> The T cell compartment must contain diversity in both TCR repertoire and cell state to provide effective immunity against pathogens 1,2 . However, it remains unclear how differences in the TCR contribute to heterogeneity in T cell state at the single cell level because most analysis of the TCR repertoire has, to date, aggregated information from populations of cells. Single cell RNA-sequencing...

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Literature Corpus work: d5ac34aa-e585-5a1c-8795-cd06f49e859b
DOI: 10.1101/072744

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