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Article

Contribution of hippocampal and extra-hippocampal NR2B-containing NMDA receptors to performance on spatial learning tasks.

Neuron - 10 Dec 2008

von Engelhardt Jakob, Doganci Beril, Jensen Vidar, Hvalby Øivind, Göngrich Christina, Taylor Amy, Barkus Chris, Sanderson David J, Rawlins J Nicholas P, Seeburg Peter H, Bannerman David M, Monyer Hannah

Abstract excerpt

Controversy revolves around the differential contribution of NR2A- and NR2B-containing NMDA receptors, which coexist in principal forebrain neurons, to synaptic plasticity and learning in the adult brain. Here, we report genetically modified mice in which the NR2B subunit is selectively ablated in principal neurons of the entire postnatal forebrain or only the hippocampus. NR2B ablation resulted in smaller NMDA...

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Identifiers

PMID: 19081379
DOI: 10.1016/j.neuron.2008.09.039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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