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Article

Selective dopamine D2 receptor deletion from Nkx6.2 expressing cells causes impaired cognitive, motivation and anxiety phenotypes in mice.

Scientific reports - 9 Nov 2023

Bechelli Lucila, Tomasella Eugenia, Cardoso Sofia Lopez, Belmonte Martina, Gelman Diego M

Abstract excerpt

Abnormal dopamine neurotransmission is a common trait of some psychiatric diseases, like schizophrenia or bipolar disorder. Excessive dopaminergic tone in subcortical brain regions is associated with psychotic episodes, while reduced prefrontal dopaminergic activity is associated with impaired cognitive performance and reduced motivation, among other symptoms. Inhibitory interneurons expressing the calcium...

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Identifiers

PMID: 37945756
DOI: 10.1038/s41598-023-46954-8
PMCID: PMC10636105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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