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Impact of NRSN2 Deficiency on Memory: Disruption of Excitatory Synaptic Plasticity Linked to Reduced Expression of NMDA Receptor Subunits and impaired LTP in the hippocampus

2025-09-01

Abstract excerpt

<title>Abstract</title> <p>Our earlier human studies identified <italic>NRSN2</italic> (Neurensin-2), a neuronal-specific vesicular protein, as a candidate gene contributing to 20p13 microdeletion syndrome, yet the mechanisms linking <italic>NRSN2</italic> deficiency to the core phenotypes remain unknown. To elucidate the function of <italic>Nrsn2</italic> in neurodevelopment and cognitive function, we generated...

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Literature Corpus work: 13f9ee6a-ae83-5558-b4e3-aa4bfc4dbc8c
DOI: 10.21203/rs.3.rs-7323201/v1

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