Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hyperactivity, startle reactivity and cell-proliferation deficits are resistant to chronic lithium treatment in adult Nr2e1(frc/frc) mice.

Genes, brain, and behavior - 1 Oct 2010

Wong B K Y, Hossain S M, Trinh E, Ottmann G A, Budaghzadeh S, Zheng Q Y, Simpson E M

Abstract excerpt

The NR2E1 region on Chromosome 6q21-22 has been repeatedly linked to bipolar disorder (BP) and NR2E1 has been associated with BP, and more specifically bipolar I disorder (BPI). In addition, patient sequencing has shown an enrichment of rare candidate-regulatory variants. Interestingly, mice carrying either spontaneous (Nr2e1(frc) ) or targeted (Tlx(-) ) deletions of Nr2e1 (here collectively known as Nr2e1-null)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimanic Agents
Share to Avoidance Learning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evoked Potentials, Auditory, Brain Stem

Share to Habituation, Psychophysiologic

Share to Hindlimb Suspension

Share to Hyperkinesis

Share to Lithium Chloride

Share to Reflex, Startle

Source

Open in PubMed Open full text

Identifiers

PMID: 20497236
DOI: 10.1111/j.1601-183X.2010.00602.x
PMCID: PMC3292041

Genes

BPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hyperactivity, startle reactivity and cell-proliferation deficits are resistant to chronic lithium treatment in adult Nr2e1(frc/frc) mice.PMID 20497236Read ↗

A new mouse model for mania shares genetic correlates with human bipolar disorder.Semantic proximity Read ↗

Long non-coding RNA Neat1 regulates adaptive behavioural response to stress in miceSemantic proximity Read ↗

Retina restored and brain abnormalities ameliorated by single-copy knock-in of human NR2E1 in null mice.Semantic proximity Read ↗

Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions.Semantic proximity Read ↗

Neuronal deletion of CaV1.2 is associated with sex-specific behavioral phenotypes in mice.Semantic proximity Read ↗

A suite of engineered mice for interrogating psychedelic drug actionsSemantic proximity Read ↗

( <i>R,S</i> )-ketamine’s rapid-acting antidepressant effects are modulated by NR2B-containing NMDA receptors on adult-born hippocampal neuronsSemantic proximity Read ↗

Latrophilin-3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity.Semantic proximity Read ↗

Decreased nesting behavior, selective increases in locomotor activity in a novel environment, and paradoxically increased open arm exploration in Neurogranin knockout mice.Semantic proximity Read ↗

Early-life scarcity adversity biases behavioral development toward a bipolar-like phenotype in mice heterozygous for CNTNAP2Semantic proximity Read ↗

Cnksr2 Loss in Mice Leads to Increased Neural Activity and Behavioral Phenotypes of Epilepsy-Aphasia Syndrome.Semantic proximity Read ↗

The selective 5-HT <sub>1A</sub> receptor biased agonist, NLX-101, corrects anomalous behavioral phenotype in a mouse model of Fragile X syndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.