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Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder.

Molecular psychiatry - 1 May 2015

Zhao Zhongming, Xu Jiabao, Chen Jingchun, Kim Sanghyeon, Reimers Mark, Bacanu Silviu-Alin, Yu Hui, Liu Chunyu, Sun Jingchun, Wang Quan, Jia Peilin, Xu Fengping, Zhang Yong, Kendler Kenneth S, Peng Zhiyu, Chen Xiangning

Abstract excerpt

Schizophrenia (SCZ) and bipolar disorder (BPD) are severe mental disorders with high heritability. Clinicians have long noticed the similarities of clinic symptoms between these disorders. In recent years, accumulating evidence indicates some shared genetic liabilities. However, what is shared remains elusive. In this study, we conducted whole transcriptome analysis of post-mortem brain tissues (cingulate cortex)...

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PMID: 25113377
DOI: 10.1038/mp.2014.82
PMCID: PMC4326626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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