Article

Detecting T-cell receptors involved in immune responses from single repertoire snapshots

2018-07-23

Abstract excerpt

Hypervariable T-cell receptors (TCR) play a key role in adaptive immunity, recognising a vast diversity of pathogen-derived antigens. High throughput sequencing of TCR repertoires (RepSeq) produces huge datasets of T-cell receptor sequences from blood and tissue samples [1, 2]. However, our ability to extract clinically relevant information from RepSeq data is limited, mainly because little is known about TCR-dise...

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Literature Corpus work: 007a12e6-f5ac-546e-b85f-99490f0f63a4
DOI: 10.1101/375162

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