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Article

Detection of Enriched T Cell Epitope Specificity in Full T Cell Receptor Sequence Repertoires

29 Nov 2019

Abstract excerpt

High-throughput T cell receptor (TCR) sequencing allows the characterization of an individual's TCR repertoire and directly queries their immune state. However, it remains a non-trivial task to couple these sequenced TCRs to their antigenic targets. In this paper, we present a novel strategy to annotate full TCR sequence repertoires with their epitope specificities. The strategy is based on a machine learning...

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PMID: 31849987
DOI: 10.3389/fimmu.2019.02820

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