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Article

Inference of SARS-CoV-2 exposure biomarkers using large-scale T-cell repertoire profiling

12 Feb 2026

Abstract excerpt

BACKGROUND: The COVID-19 pandemic offers a powerful opportunity to develop methods for monitoring the spread of infectious diseases based on their signatures in population immunity. Adaptive immune receptor repertoire sequencing (AIRR-seq) has become the method of choice for identifying T cell receptor (TCR) biomarkers encoding pathogen specificity and immunological memory. AIRR-seq can detect imprints of past...

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PMID: 41680899
DOI: 10.1186/s13073-025-01589-4

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