Back to search

Article

Cocaine Acts Through Sigma-1 to Enhance HIV Infection of Microglia

2025-08-07

Abstract excerpt

Cocaine use disorder is highly comorbid in people with HIV and can accelerate infection, alter neuropathology, and exacerbate cognitive decline despite antiretroviral therapy (ART). Many of these effects are due to infection and dysregulation of CNS myeloid cells, especially microglia, which comprise a significant reservoir in this compartment. However, the precise mechanism(s) by which cocaine (Coc) enhances HIV...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
006da025-42c3-5f64-a250-d7ce83b17eda
DOI
10.1101/2025.08.06.668840
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Cocaine Acts Through Sigma-1 to Enhance HIV Infection of MicrogliaDOI 10.1101/2025.08.06.668840
Transcriptional impacts of substance use disorder and HIV on human ventral midbrain neurons and microgliaSemantic proximity
Neuroinflammation and EIF2 signaling persist in an HiPSC tri-culture model of HIV infection despite antiretroviral treatmentSemantic proximity
STAT1-Mediated Regulation of IL-17A/CEBPB/NF-κB Axis in HIV-1 Infected Human Cerebral Organoids Reveals Therapeutic Targets for NeuroprotectionSemantic proximity
Multi-omic Characterization of HIV Effects at Single Cell Level across Human Brain RegionsSemantic proximity
A Human iPSC-Derived Tri-Culture Model of NeuroHIV: HIV Infection, Antiretroviral Drug Effects, Microglial Morphology, and Neuronal Calcium DynamicsSemantic proximity
Investigation of CNS damage following HIV infection and methamphetamine exposure using human iPSC-derived microglia and 3D cerebral assembloid modelsSemantic proximity
Opioid-induced transcriptional reprogramming of cerebrospinal fluid immune cells drives neuroinflammation in SIV-infected rhesus macaquesSemantic proximity
Dysregulated neuroimmune interactions and sustained type I interferon signaling after human immunodeficiency virus type 1 infection of human iPSC derived microglia and cerebral organoidsSemantic proximity
HIV-1 infection of human microglia activates inflammatory pathways associated with HIV-associated neurocognitive disorders (HAND)Semantic proximity
Transcriptional Mapping of Neuro-Immune Interactions during Homeostasis and HIV infection using Microglia-containing Human Cerebral AssembloidsSemantic proximity
Human microglial models to study HIV infection and neuropathogenesis: a literature overview and comparative analysesSemantic proximity
Neurological impact of HIV/AIDS and substance use alters brain function and structureSemantic proximity
Select a neighboring publication to make it the new centre.