Article

Opioid-induced transcriptional reprogramming of cerebrospinal fluid immune cells drives neuroinflammation in SIV-infected rhesus macaques

2026-02-05

Abstract excerpt

<title>Abstract</title> <p> Background. Opioid use is disproportionately high among People with HIV (PWH). Although combined anti-retroviral therapy (ART) can dampen HIV-associated dementia, a large fraction of PWH continue to experience neurocognitive deficits which are further exacerbated by opioid use. In the present study, we performed single cell transcriptomic profiling of cerebrospinal fluid (CSF) immune...

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Literature Corpus work: 6b5c97e9-94f4-55db-8023-7b808664b029
DOI: 10.21203/rs.3.rs-8632387/v1

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